C20-3032-174-1577

C20 abstract preview

(#174) Antibiotic Prescribing Pattern and Cost of Antibiotic for Upper Respiratory Tract Infection in Primary Health-care Site, Melaka Tengah

Abstract:

Introduction: Antibiotics have been used for decades to effectively treat of bacterial infections. They are often prescribed inappropriately and inadequately, thus have become one of the highly abused drugs. The widespread misuse of antibiotics not only increased the cost of treatment but has also resulted in the emergence of antibiotic resistant pathogens.

Objectives: This study aimed to assess whether the antibiotic prescribing pattern for upper respiratory tract infection (URTI) in the primary healthcare site, Melaka Tengah is adherent to the National Antibiotic Guideline (NAG) 2014, as well as to identify factors related to antibiotic prescribing pattern and to calculate the mean cost antibiotic prescribed.

Methods: A retrospective study was conducted within one month of October 2017. Patients who visited government clinics in Melaka Tengah and diagnosed with URTI were recruited. Data obtained were analyzed via SPSS version 20.

Results: 4,115 prescriptions with diagnosis of URTI were included in the study and 710 prescriptions (17.25%) were prescribed with antibiotic. Among 11 Health Clinics, Klinik Kesihatan Tengkera has the highest antibiotic prescribed about 34.4% followed by Klinik Kesihatan Ujong Pasir 32.2% and Klinik Kesihatan Bukit Rambai 28.8%. The mostly prescribed antibiotic was amoxicillin (66.2%) followed by erythromycin (33.2%). There were significant differences in antibiotic prescribing pattern in terms of area and types of clinic and no significant differences in terms of patient’s age, gender, doctor’s graduate school and service year. Mean cost antibiotic per prescription of Klinik Kesihatan Bukit Rambai (RM25.30) was the highest among all clinics, followed by Klinik Kesihatan Jalan Gereja (RM21.70) and Klinik Kesihatan Seri Tanjung (RM17.70).

Conclusion: This study showed antibiotic prescribing pattern for URTI in government clinics in Melaka Tengah is adherent to NAG 2014. However, Medical Officers need to specify the indication as well as stating the strep score in the prescription.

Keywords:

antibiotic, antibiotic prescribing pattern, upper respiratory tract infection, antibiotic cost, National Antibiotic Guideline

Abstract document:

xabstract-509.docx

Does this research add new knowledge to the existing literature?:

Yes.
Most of the existing literature reviews in Malaysia were done to study antibiotic prescription rate and examine factors that are related to the prescribing pattern. However, from what we have found, none was done to survey the cost of antibiotics that has been spent for each Upper Respiratory Tract Infection (URTI) prescription, indicating the amount of money that can be saved if antibiotics were prescribed appropriately and only when necessary. Besides, this research also assessed whether the antibiotic prescribing pattern for URTI patients was adherent to the National Antibiotic Guideline (NAG) edition 2014, which was seldom done by other researches.

Has the knowledge been translated into practice?:

Yes.
The prescribers are now required to state the modified Centor (Strep) score on each URTI prescription with antibiotic. This is because this research found out that all antibiotic prescriptions which were collected during the study period did not state the modified Centor score, hence we could not decide whether the antibiotic prescribing was appropriate. According to NAG 2014, antibiotic should only be prescribed for patients with modified Centor score ≥3 since most of the infections are commonly viral in origin.

Does your research fit the conference theme?:

Yes.
This research was conducted to optimize drug therapy outcome in patients. Prescribers are encouraged to adhere to NAG during antibiotic prescribing to achieve the goals of antimicrobial stewardship. According to the protocol released by KKM in 2014, antimicrobial stewardship was developed to maximize clinical cure or prevent infections by promoting judicious use of antimicrobials, to limit the emergence of antimicrobial resistance and adverse drug events, and also to reduce healthcare cost without adversely impacting quality of care.

Research track:

Optimization of therapy

Preference of presentation:

Poster
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Introduction: 
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Keywords: 
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The concordance of study to the conference’s theme: 
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Comment: 
The results do not answer the objective completely. The results do not indicate adherence to the NAG. Additionally the conclusion does not relate to the results.
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